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Gene Therapy
Scientists at National Cheng-Kung University, Institute of Basic Medical Science target gene therapy
May 6th, 2008
Data detailed in 'Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway' have been presented. According to a study from Tainan, Taiwan, "Ceramide, a tumor-suppressor lipid, is generated by sphingomyelin hydrolysis or by de novo synthesis when cells are activated by various stress stimuli as well as when cancer cells are subjected to genotoxic chemotherapy. Ceramide may modulate apoptotic signaling pathways; however, its transcription-dependent effects remain unclear." "Our data showed that actinomycin D partially inhibited ceramide-induced apoptosis. Using microarray analysis, we found that ceramide...
Source: Cancer Weekly (2008-05-06)
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