Cancer Weekly
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Adenovirus
Research from H.L. Li and colleagues provide new insights into adenovirus
May 6th, 2008
According to recent research from Guangzhou, People's Republic of China, "Angiogenesis plays a pivotal role in tumor growth, tissue invasion and metastasis. Endostatin is an angiogenesis inhibitor and has been shown to reduce tumor growth in animal models." "However, therapy with recombinant endostatin protein was hampered by its short half-life and very-low yield of bioactive protein. We performed a phase I dose escalation clinical trial using intratumoral injection of an adenovirus containing human endostatin gene (Ad-rhE; E10A; 10(10)-10(12) virus particles (vp)) in 15 patients with advanced solid tumors. We observed intratumoral injections of E10A without...
Source: Cancer Weekly (2008-05-06)
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