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Angiogenesis
Findings from Harvard University in angiogenesis reported
May 6th, 2008
"Type IV collagen is a major component of vascular basement membranes. The noncollagenous (NC1) domains of several alpha-chains of type IV collagen reveal a capacity to inhibit angiogenesis and tumor growth," scientists writing in the International Journal of Cancer report. "Here, we demonstrate that the NC1 domain of the alpha 6 chain of type IV collagen (alpha 6NC1) is an endogenous inhibitor of angiogenesis and tumor growth. Recombinant alpha 6NC1 inhibits human endothelial cell proliferation and neovascularization of Matrigel plugs in mice. The alpha 6NC1 suppresses the growth of subcutaneously transplanted Lewis lung carcinoma and also spontaneous pancreatic...
Source: Cancer Weekly (2008-05-06)
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