Cancer Weekly
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Angiogenesis
Studies from T. Yi et al add new findings in the area of angiogenesis
May 6th, 2008
According to recent research published in the journal Cancer Research, "Gambogic acid (GA), the main active compound of Gamboge hanburyi, has been previously reported to activate apoptosis in many types of cancer cell lines by targeting transferrin receptor and modulating nuclear factor-kappa B signaling pathway. Whether GA inhibits angiogenesis, which is crucial for cancer and other human diseases, remains unknown." "Here, we found that GA significantly inhibited human umbilical vascular endothelial cell (HUVEC) proliferation, migration, invasion, tube formation, and microvessel growth at nanomolar concentration. In a xenograft prostate tumor model, we found...
Source: Cancer Weekly (2008-05-06)
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