Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy study findings have been published by scientists at University of Manchester
May 6th, 2008
According to recent research from Manchester, the United Kingdom, "Alkylating agents are frequently used in the chemotherapy of many types of cancer. This group of drugs mediates cell death by damaging DNA and therefore, understandably, cellular DNA repair mechanisms can influence both their antitumour efficacy and their dose-limiting toxicities." "Sources of data: This review focuses on the mechanism of action of the DNA repair protein, O-6-methylguanine-DNA methyltransferase (MGMT) and its exploitation in cancer therapy and reviews the current literature. Areas of agreement: MGMT can provide resistance to alkylating agents by DNA damage reversal. Inhibition of tumour...
Source: Cancer Weekly (2008-05-06)
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