Cancer Weekly
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Apoptosis
Studies from Massachusetts General Hospital add new findings in the area of apoptosis
May 6th, 2008
According to recent research from the United States, "One of the physiologic consequences of excessive UV radiation (UVR) exposure is apoptosis. This critical response serves to eliminate genetically injured cells and arises, in part, from activation of DNA damage and p53 signaling." "Other contributory pathways, however, likely exist but have not been fully characterized. In a recent global screen of UVR response genes in melanocytes, we identified the receptor tyrosine kinase EPHA2. Using a combination of genetic and pharmacologic approaches, we set out to investigate the upstream regulation of EphA2 by UVR and the functional consequences of this effect. We found that...
Source: Cancer Weekly (2008-05-06)
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