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Apoptosis
Studies in the area of apoptosis reported from University of Calabria
May 6th, 2008
According to a study from Italy, "Ferulic acid plays a chemopreventive role in cancer by inducing tumor cells apoptosis." "As mitochondria play a key role in the induction of apoptosis in many cells types, here we investigate the mitochondrial permeability transition (MPT) and the release of cytochrome c induced by ferulic acid and its esters in rat testes mitochondria, in TM-3 and MLTC-1 cells. While ferulic acid, but not its esters, induced MPT and cytochrome c release in rat testes isolated mitochondria, in TM-3 cells we found that both ferulic acid and its esters induced cytochrome c release from mitochondria in a dose-dependent manner, suggesting a potential target...
Source: Cancer Weekly (2008-05-06)
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