Cancer Weekly
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Bioengineering
Research in the area of bioengineering reported from P. Sapra and colleagues
May 6th, 2008
"Clinical development of SN38, the active metabolite of camptothecin-11 (CPT-11), has been hampered due to its poor solubility. We have developed a novel polymer-drug conjugate, EZN-2208, made by linking SN38 with a multiarm polyethylene glycol via a glycine linker," scientists writing in the journal Clinical Cancer Research report. "The in vitro cytotoxicity of EZN-2208 was tested using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. The therapeutic efficacy of EZN-2208 was evaluated in various xenografts, including an in vivo selected CPT-11 - refractory model. Tumor and blood concentration of EZN-2208,...
Source: Cancer Weekly (2008-05-06)
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