Cancer

Investigators at Northwestern University, Medical Department publish new data on cancer

Published in Cancer Weekly, May 13th, 2008

According to recent research published in the journal Molecular Cancer Research, "Oral squamous cell carcinoma (OSCC), which is the most common malignancy of the oral cavity, is often associated with local and regional invasion. Increased expression of matrix metalloproteinase-9 (MMP-9) is correlated with invasive behavior of OSCC."

"Because transforming growth factor beta 1 (TGF-beta 1) is up-regulated in OSCC tumors, we examined the relationship between TGF-beta 1 signaling and MMP-9 in human OSCC specimens. Evaluation of human specimens showed that tumors with enhanced TGF-beta 1 signaling also showed increased MMP-9 expression. Because the transcription...

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Source: Cancer Weekly (2008-05-13)

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