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Cancer Gene Therapy
New cancer gene therapy findings from University of Maastricht described
May 13th, 2008
Research findings, 'Delivery of a DNAzyme targeting c-myc to HT29 colon carcinoma cells using a gold nanoparticulate approach,' are discussed in a new report. "The objective of the current study was to develop cellular delivery approaches for catalytic DNA enzymes (DNAzymes) which cleave targeted messenger RNA, using vectors based on colloidal gold. The model DNAzyme was a 32mer oligonucleotide designed to specifically interact with and cleave c-myc mRNA," researchers in Maastricht, Netherlands report. "Colloidal gold particles were prepared by reduction of tetrachlororauric [III] acid with sodium citrate. Particles could be produced in the 1-90 nm range. A cationic...
Source: Cancer Weekly (2008-05-13)
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