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Cancer Gene Therapy
Researchers at University of Texas, M. D. Anderson Cancer Center release new data on cancer gene therapy
May 13th, 2008
Fresh data on cancer gene therapy are presented in the report 'Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer.' "Tissue transglutaminase (TG2) is a multifunctional protein that is implicated in development of drug resistance and metastasis. Therefore, we examined therapeutic targeting of TG2 for inhibiting growth and metastasis of in vivo growing pancreatic ductal adenocarcinoma (PDAC) in nude mice," scientists in the United States report. "We implanted Panc-28 pancreatic cancer cells to induce orthotopic PDAC tumors in nude mice and determined the efficacy of liposomal TG2 small interfering RNA (siRNA) either alone or in...
Source: Cancer Weekly (2008-05-13)
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