Cancer Weekly
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Acute Myelogenous Leukemia
Reports outline acute myelogenous leukemia research from University of Medicine and Dentistry of New Jersey
May 13th, 2008
According to recent research from the United States, "Resistance to topoisomerase I (TOP1)-targeting drugs such as topotecan often involves upregulation of topoisomerase II (TOP2), with accompanying increased sensitivity to TOP2-targeting drugs such as etoposide. This trial was designed to investigate sequential topoisomerase targeting in the treatment of patients with high-risk acute myelogenous leukemia." "An initial cohort of patients received topotecan and cytosine arabinoside daily for 5 days. Serial samples of circulating mononuclear cells were examined to evaluate peak elevations of TOP2-alpha protein expression. In subsequent cohorts, etoposide was administered...
Source: Cancer Weekly (2008-05-13)
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