Cancer Weekly
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Angiogenesis
New angiogenesis study findings have been reported by J.Y. Wang and co-researchers
May 13th, 2008
According to recent research from the United States, "This laboratory and others have shown that agents that inhibit the in vitro catalytic activity of methionine aminopeptidase-2 (MetAP2) are effective in blocking angiogenesis and tumor growth in preclinical models. However, these prototype MetAP2 inhibitors are clearly not optimized for therapeutic use in the clinic." "We have discovered an orally active class of MetAP2 inhibitors, the anthranilic acid sulfon-amides exemplified by A-800141, which is highly specific for MetAP2. This orally bioavailable inhibitor exhibits an antiangiogenesis effect and a broad anticancer activity in a variety of tumor xenografts...
Source: Cancer Weekly (2008-05-13)
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