Cancer Weekly
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Angiogenesis
Research results from University of Regensburg update understanding of angiogenesis
May 13th, 2008
"Background and aims Activation of the mitogen-activated protein kinase-extracellular-signal-regulated kinase (ERK) pathways plays an important role in the progression of hepatocellular carcinoma (HCC). Importantly, Raf kinases are principal effectors within this oncogenic signaling cascade," scientists in Regensburg, Germany report. "We hypothesized that concomitant inhibition of Raf and vascular endothelial growth factor receptor 2 (VEGFR2) will affect tumor growth and angiogenesis of HCC. Materials and methods Human HCC cell lines, endothelial cells (EC), and vascular smooth muscle cells (VSMC) were used. For blocking Raf kinase and VEGFR2, the small molecule...
Source: Cancer Weekly (2008-05-13)
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