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Apoptosis
Research on apoptosis discussed by scientists at Kagoshima University
May 13th, 2008
"There is evidence for defects in the mechanisms that allow the activation of p53 in many of the cancers that retain wild-type p53. Reactivation of p53 has been suggested to be an effective strategy for cancer therapy in wild-type p53-retained tumor cells," scientists writing in the journal Bioscience Biotechnology and Biochemistry report. "In the present study, we attempted to reactivate p53 in HepG2 retaining wild-type p53 by quercetin, an ubiquitous bioactive plant flavonoid. Our results show that quercetin inhibited the proliferation of HepG2 cells through the induction of cell cycle arrest and apoptosis, as characterized by the cell cycle distribution and...
Source: Cancer Weekly (2008-05-13)
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