Cancer Weekly
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Bladder Cancer
Recent findings from University of North Dakota highlight research in bladder cancer
May 13th, 2008
"Cadmium and arsenite can directly and malignantly transform the UROtsa cell line. The tumor heterotransplants produced from these transformed cells have histologic features consistent with human bladder cancer," investigators in the United States report. "Previous microarray analysis of total RNA from the parental and transformed cells suggested that keratin 6a was overexpressed as a result of cell transformation. Our goals were to verify overexpression of keratin 6a in Cd2+- and As3+ -transformed UROtsa cells, the corresponding tumor heterotransplants, and human bladder cancer biopsy specimens and to assess what factors may be involved in keratin 6a overexpression....
Source: Cancer Weekly (2008-05-13)
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