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Cancer Weekly

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Cancer Gene Therapy



Research from China Pharmaceutical University in cancer gene therapy provides new insights



May 20th, 2008

Researchers detail in 'Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells,' new data in cancer gene therapy. According to a study from Nanjing, People's Republic of China, "We previously reported that gambogic acid (GA), a natural product, was an effective telomerase inhibitor by repressing hTERT promoter. In this study, posttranscriptional regulation of the telomerase hTERT by GA was investigated in BGC-823 human gastric carcinoma cells."

"The telomerase activity was detected by PCR-TRAP assay. RT-PCR assay and Western blot were performed to examine the repression of telomerase hTERT and c-Myc after GA or...


Source: Cancer Weekly (2008-05-20)

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