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Gene Therapy
Researchers from University of Pennsylvania report on findings in gene therapy
May 20th, 2008
Researchers detail in 'Novel adenoviral gene delivery system targeted against head and neck cancer,' new data in gene therapy. "The clinical applicability of adenovirus-mediated gene therapy is limited by the lack of tumor-targeted strategies. Ubiquitous expression of the coxsackie-adenovirus receptor, the native binding site for adenovirus, broadens viral tropism and increases systemic toxicity," scientists in the United States report. "Adenoviruses can be genetically engineered to target tumor-specific cell surface biomarkers. Here, we present a novel recombinant adenovirus vector (Ad5-Flag-LDS) that demonstrated a marked targeting bias against Hsp47, a biomarker for...
Source: Cancer Weekly (2008-05-20)
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