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Gene Therapy
Researchers' work from University of Cincinnati, Department of Environmental Health focuses on gene therapy
May 20th, 2008
Data detailed in 'Repression of Ah receptor and induction of transforming growth factor-beta genes in DEN-induced mouse liver tumors' have been presented. According to recent research from the United States, "The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the biologic and toxic effects of its xenobiotic ligands. In recent years it has become evident that in the absence of ligand the AHR promotes cell cycle progression and that its activation by high-affinity ligands results in interactions with the retinoblastoma protein (RB) that lead to perturbation of the cell cycle, G0/G1 arrest, diminished capacity for DNA replication and inhibition of...
Source: Cancer Weekly (2008-05-20)
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