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HIV/AIDS Therapy
Research from National Cancer Institute reveals new findings on HIV/AIDS therapy
May 20th, 2008
Investigators publish new data in the report 'Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.' According to a study from the United States, "The importance of chronic immune activation in progression to AIDS has been inferred by correlative studies in HIV-infected individuals and in nonhuman primate models of SIV infection. Using the SIV(mac251) macaque model, we directly address the impact of immune activation by inhibiting CTLA-4, an immunoregulatory molecule expressed on activated T cells and a subset of regulatory T cells." "We found that CTLA-4 blockade significantly increased T...
Source: Cancer Weekly (2008-05-20)
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