Cancer Weekly
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Life Sciences
Research on life sciences discussed by scientists at University of Colorado, Colorado Health Sciences Center
May 20th, 2008
Investigators publish new data in the report 'Age-dependent tolerance to an endogenous tumor-associated antigen.' According to recent research from the United States, "Immunologic tolerance to endogenous antigens reduces antitumor responses. Gp70 is an endogenous tumor-associated antigen (TAA) of the BALB/c-derived colon carcinoma CT26." "We found that expression of gp70 mRNA is detectable in tissues of mice 8 months of age and older. We showed that expression of gp70 establishes immunologic tolerance and affects antitumor immunity in a similarly age-dependent manner using gp70-deficient mice. We found that tumors grew in all gp70-sufficient mice, while approximately...
Source: Cancer Weekly (2008-05-20)
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