Liver Cancer

Reports by C.B. Rountree and co-researchers describe recent advances in liver cancer

Published in Cancer Weekly, May 20th, 2008

According to a study from the United States, "Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the biosynthesis of S-adenosylmethionine. Hepatic MAT activity falls in chronic liver diseases, and mice lacking Mat1a are predisposed to liver injury and develop hepatocellular carcinoma (HCC) spontaneously by 18 months."

"The current work examined the hypothesis that liver cancer stem cells contribute to HCC in this model. Livers from 6- and 18-month-old Mat1a-knockout (KO) mice and their wild-type (WT) littermates were fractionated and isolated by flow cytometry. CD45-nonparenchymal (NP) cells were cultured using liver stem cell conditions. Cells...

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Source: Cancer Weekly (2008-05-20)

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