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Alzheimer Disease
Scientists at RIKEN publish research in Alzheimer disease
May 20th, 2008
According to recent research from Wako, Japan, "The proinflammatory cytokine interleukin (IL)-1 beta is up-regulated in microglial cells surrounding amyloid plaques, leading to the hypothesis that IL-1 beta is a risk factor for Alzheimer's disease. However, we unexpectedly found that IL-1 beta significantly enhanced alpha-cleavage, indicated by increases in sAPP alpha and C83, but reduced beta-cleavage, indicated by decreases in sAPP beta and A beta 40/42, in human neuroblastoma SK-N-SH cells." "IL-1 beta did not significantly alter the mRNA levels of BACE1, ADAM-9, and ADAM-10, but up-regulated that of TACE by threefold. The proform and mature form of TACE protein were...
Source: Cancer Weekly (2008-05-20)
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