Cancer Weekly
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Angiogenesis
New angiogenesis findings from M. Dai and co-authors described
May 20th, 2008
According to a study from Beijing, People's Republic of China, "Melatonin is an important natural oncostatic agent. At present there are no data available as to its possible influence on tumor angiogenesis, which is a major biological mechanism responsible for tumor growth and dissemination." "It is well known that vascular endothelial growth factor (VEGF) is crucial to a solid tumor's higher vascularization and development. To investigate the possible influence of melatonin on angiogenesis, we studied the effect of melatonin on endogenous VEGF expression in three human cancer cell lines (PANC-1, HeLa and A549 cells). In this study, we report that physiologic...
Source: Cancer Weekly (2008-05-20)
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