Cancer Weekly
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Angiogenesis
Research from University of Bristol provides new data on angiogenesis
May 20th, 2008
According to recent research from Bristol, the United Kingdom, "Vascular endothelial growth factor-A is widely regarded as the principal stimulator of angiogenesis required for tumour growth. VEGF is generated as multiple isoforms of two families, the pro-angiogenic family generated by proximal splice site selection in the terminal exon, termed VEGF(xxx), and the anti-angiogenic family formed by distal splice site selection in the terminal exon, termed VEGF(xxx)b, where xxx is the amino acid number." "The most studied isoforms, VEGF(165) and VEGF(165)b have been shown to be present in tumour and normal tissues respectively. VEGF165b has been shown to inhibit VEGF- and...
Source: Cancer Weekly (2008-05-20)
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