Cancer Weekly
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Angiogenesis
Study findings from W. Wrasidlo et al provide new insights into angiogenesis
May 20th, 2008
According to recent research from the United States, "Screening for novel anticancer drugs in chemical libraries isolated from marine organisms, we identified the lipopeptide somocystinamide A (ScA) as a pluripotent inhibitor of angiogenesis and tumor cell proliferation. The antiproliferative activity was largely attributable to induction of programmed cell death." "Sensitivity to ScA was significantly increased among cells expressing caspase 8, whereas siRNA knockdown of caspase 8 increased survival after exposure to ScA. ScA rapidly and efficiently partitioned into liposomes while retaining full antiproliferative activity. Consistent with the induction of apoptosis...
Source: Cancer Weekly (2008-05-20)
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