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Apoptosis
Scientists at University of Tokyo publish new data on apoptosis
May 20th, 2008
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "Apoptosis is a highly regulated process of cell suicide that occurs during development, host defense, and pathophysiology. The transcription factor IFN regulatory factor 5 (IRF5), known to be involved in the activation of innate immune responses, recently has been shown to be critical for DNA damage-induced apoptosis and tumor suppression." "Here, we report on a cell-type-specific role of IRF5 in promoting apoptosis upon signaling through the death receptor Fas (CD95/APO-1/TNFRSF6). In particular, we show that mice deficient in...
Source: Cancer Weekly (2008-05-20)
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