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Cancer Gene Therapy
New cancer gene therapy study results reported from Medical College of Wisconsin, Medical College
May 27th, 2008
According to recent research from the United States, "We previously demonstrated that 15-LOX-2 is significantly reduced in head and neck carcinoma and restoration of 15-LOX-2 expression results in tumor inhibition in HNC. The aim of this study is to evaluate 15-LOX-2 as a candidate for targeted radiotherapy." "Molecular subcloning was performed to create a radiation-inducible 15-LOX-2 expression vector in which the full-length 15-LOX-2 cDNA was inserted downstream the recombinant Egr-1 promoter. The radiation-induced downregulations of 15-LOX-2 protein ( twofold up) and its main metabolite 15S-HETE ( threefold up) were observed in HNC cells transfected with the 15-LOX-2...
Source: Cancer Weekly (2008-05-27)
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