Cancer Weekly
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Cancer Vaccines
Research findings from M.R.L. Young et al update understanding of cancer vaccines
May 27th, 2008
"Select groups of premalignant oral lesions carry a high risk of development of secondary premalignant lesions and oral squamous cell carcinoma (OSCC). The goal of the present study was to determine the feasibility of using premalignant lesion-pulsed dendritic cells as a treatment option to prevent development of secondary lesions and development of OSCC," scientists in the United States report. "Mice that were treated with the carcinogen 4-nitroquinoline-l-oxide (4NQO) developed premalignant oral lesions and, subsequently, OSCC. Immunohistochemical analyses showed that these 4NQO-induced lesions and OSCC both overexpressed the tumor antigens epidermal growth factor...
Source: Cancer Weekly (2008-05-27)
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