Cancer Weekly
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Cancer Vaccines
Research on cancer vaccines reported by G.E. Parris et al
May 27th, 2008
"Most enveloped viruses fuse with host cells and catalyze fusion among host cells by expression of specific patterns of N-glycosylation on their envelope proteins. In the 1970s, it was observed that 2-deoxy-D-glucose (2DOG) and 2-fluoro-2-deoxy-D-mannose (2F2DOM) inhibited N-glycosylation of asparagine (Asn) sites on the external domain of viral envelope proteins," scientists in the United States report. "This effect led to the virus particles being non-fusogenic with greatly reduced infectivity and reduced ability to pass from cell to cell by catalyzing cell-cell fusion. At that time, this observation was not particularly important because viral diseases were readily...
Source: Cancer Weekly (2008-05-27)
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