Published in Cancer Weekly, May 27th, 2008
"To study if the lack of pol eta significantly elevates spontaneous mutation frequency in various organs and tissues of the mouse, we crossed pol eta-deficient mice with transgenic mice harboring a chromosomally integrated lacZ-plasmid reporter construct. In cultured embryonic fibroblasts from the lacZ-polq(-/-) mice, 2.5 J/m(2) UV irradiation induced similar to...
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