Cancer Research

Research from R.A. Busuttil and colleagues has provided new data on cancer research

Published in Cancer Weekly, May 27th, 2008

"The low-fidelity polymerase eta (pol eta) is required for bypass of UV-induced pyrimidine dimers inserting adenine nucleotides opposite these lesions. Mutations in the pol eta gene are responsible for the genetic defect in xeroderma pigmentosum variant patients," investigators in the United States report.

"To study if the lack of pol eta significantly elevates spontaneous mutation frequency in various organs and tissues of the mouse, we crossed pol eta-deficient mice with transgenic mice harboring a chromosomally integrated lacZ-plasmid reporter construct. In cultured embryonic fibroblasts from the lacZ-polq(-/-) mice, 2.5 J/m(2) UV irradiation induced similar to...

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Source: Cancer Weekly (2008-05-27)

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