Cancer Weekly
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Colon Cancer
Research reports on colon cancer from W.J. Vanhoudt and colleagues provide new insights
May 27th, 2008
According to recent research from Netherlands, "Reovirus T3D preferentially kills tumor cells expressing Ras oncogenes and has shown great promise as an anticancer agent in various preclinical tumor models. Here, we investigated whether reovirus can infect and kill tumor cell cultures and tissue fragments isolated from resected human colorectal tumors, and whether this was affected by the presence of endogenous oncogenic KRAS." "Tissue fragments and single-cell populations isolated from human colorectal tumor biopsies were infected with reovirus virions or with intermediate subviral particles (ISVPs). Reovirus virions were capable of infecting neither single-cell tumor...
Source: Cancer Weekly (2008-05-27)
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