Cancer Weekly
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Life Sciences
Researchers from Mayo Clinic, Medical Department publish findings in life sciences
May 27th, 2008
According to recent research published in the journal Cancer Research, "Antigenically distinct tumor variants can emerge in response to selective pressures inherent to. host-tumor interactions. The development of successful immunotherapeutic strategies can be limited by these disparate antigenic profiles." "Using the immunomodulator B7-DC XAb to activate cytolytic T cells specific for tumor-associated antigens, we found that the specificity of immune responses elicited by live tumors are distinct from the specificity of the responses elicited by soluble proteins derived from the same tumors. Remarkably, whereas the induced antitumor immunity generated against...
Source: Cancer Weekly (2008-05-27)
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