Gene Therapy

Research from Baylor College of Medicine, College of Medicine yields new findings on gene therapy

Published in Cancer Weekly, May 27th, 2008

"The p53 tumor suppressor is essential in maintaining genomic integrity in response to cellular stresses. In response to DNA damage, p53 is activated and stabilized largely through post-translational modifications, including phosphorylation by DNA damage responsive kinases such as ATM and ATR," scientists writing in the journal Cell Cycle report.

"Activated p53 transactivates a battery of genes that can mediate either cell cycle arrest or apoptosis. In those instances where p53 facilitates cell cycle arrest, a means to return the cell to a pre-stress state with low p53 levels is important. The E3 ubiquitin ligase Mdm2 is one p53 transcriptional target that...

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Source: Cancer Weekly (2008-05-27)

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