Cancer Weekly
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Acute Lymphoblastic Leukemia
Research reports on acute lymphoblastic leukemia from K. Dekeersmaecker and colleagues provide new insights
May 27th, 2008
" Activating NOTCH1 mutations are common in T-cell acute lymphoblastic leukemia. Inhibition of NOTCH 1 signaling with gamma-secretase inhibitors causes cell cycle block, but only after treatment for several days," scientists in Louvain, Belgium report. "We further documented the effects of gamma-secretase inhibitor treatment on T-cell acute lymphoblastic leukemia cell lines and tested whether combining gamma-secretase inhibitors with other anti-cancer drugs offers a therapeutic advantage. Design and Methods The effect of gamma-secretase inhibitor treatment and combinations of gamma-secretase inhibitors with chemotherapy or glucocorticoids was assessed on T-cell acute...
Source: Cancer Weekly (2008-05-27)
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