Cancer Weekly
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Angiogenesis
Reports outline angiogenesis study findings from A. Safina and colleagues
May 27th, 2008
"Transforming growth factor-beta 1 (TGF-beta 1) signaling in tumor cells has been implicated in tumor angiogenesis and metastasis by regulating matrix proteolysis. Although MMP-9/gelatinase-B is an important component of these TGF-b1 responses, the mechanism of its regulation is not well understood," scientists writing in the journal Oncogene report. "Here, we present evidence that TGF-beta-activated protein kinase 1 (TAK1) is critical for TGF-beta regulation of MMP-9 and the metastatic potential of breast cancer cell line MDA-MB-231. We found that suppression of TAK1 signaling by dominant-negative (dn) TAK1 or RNA interference (siRNA) reduces expression of MMP-9...
Source: Cancer Weekly (2008-05-27)
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