Cancer Weekly
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Angiogenesis
Research data from Technical University of Munich update understanding of angiogenesis
May 27th, 2008
"Angiogenesis has been reported to be an essential step in the progression and development of carcinomas. Numerous growth factors regulate angiogenesis, however, vascular endothelial growth factor (VEGF) has been reported to be most relevant within this context.(1) The endothelium starts to proliferate, vessels migrate into the tumor, and permeability is increased after the VEGF pathway has been started," investigators in Munich, Germany report. "VEGF is up-regulated in most carcinomas, and its expression correlates positively with tumor progression and negatively with cancer prognosis. Before a tumor can grow beyond 1-2 mm, it requires blood vessels for nutrients and...
Source: Cancer Weekly (2008-05-27)
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