Cancer Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Cancer Gene Therapy
Data from University of Kuopio advance knowledge in cancer gene therapy
May 27th, 2008
According to recent research from Kuopio, Finland, "Cancer suicide gene therapy based on herpes simplex virus type I thymidine kinase (HSV-TK) and ganciclovir (GCV) suffers from the lack of efficacy in clinical use, which is mostly due to low gene-transfer efficiency and absence of bystander effect in tumors. We have previously demonstrated the enhancement of GCV cytotoxicity by fusing the HSV-TK with the cell penetrating peptide from HIV-1 transactivator protein transduction domain ( TAT PTD)." "Despite the earlier promising results, we found that the triple fusion protein HIV-1 transactivator protein transduction domain - thymidine kinase suicide gene - green...
Source: Cancer Weekly (2008-05-27)
|
