Cancer Weekly
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Enzyme Research
Data on enzyme research detailed by R.P. Dediego and co-authors
June 3rd, 2008
According to a study from Madrid, Spain, "X-linked agammaglobulinaemia (XLA) is characterized by absence of mature B cells because of mutations in the Bruton's tyrosine kinase (Btk) gene. Btk-deficient early B cell precursors experience a block in their differentiation potentially reversible by the addition of an intact Btk gene." "Btk expression was measured in 69 XLA patients with 47 different mutations and normal expression was detected in seven. We characterized these Btk mutant forms functionally by transfection into a lymphoma cell line that lacks endogenous Btk expression (Btk(-/-) DT40 cells) and analysed the calcium flux in response to B cell receptor...
Source: Cancer Weekly (2008-06-03)
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