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Lymphoma Gene Therapy
Data on lymphoma gene therapy described by researchers at Saitama Medical University, Department of Hematology
June 3rd, 2008
Current study results from the report, 'The GAS5 (growth arrest-specific transcript 5) gene fuses to BCL6 as a result of t(1;3)(q25;q27) in a patient with B-cell lymphoma,' have been published. "The BCL6 gene is frequently disrupted at its 5' noncoding region by 3q27 chromosomal translocations in B-cell lymphoma. As a result of translocation, BCL6 is juxtaposed to reciprocal partners, such as the immunoglobulin (Ig) gene family," scientists in Saitama, Japan report. "Besides the Ig loci, multiple non-Ig partners of the BCL6 translocation have been reported. Here we describe the identification of the GAS5 (growth arrest-specific transcript 5) gene as a novel partner of...
Source: Cancer Weekly (2008-06-03)
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