Acute Myeloid Leukemia
Research by R.F. Schlenk and colleagues in acute myeloid leukemia provides new insights
Published in Cancer Weekly, June 3rd, 2008
"Mutations occur in several genes in cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (FLT3), the CCAAT/enhancer binding protein (alpha) gene (CEPBA), the myeloid-lymphoid or mixed-lineage leukemia gene (MLL), and the neuroblastoma RAS viral oncogene homolog (NRAS). We evaluated the associations of these mutations with clinical outcomes in patients," researchers in Ulm, Germany report.
"We compared the mutational status of the NPM1, FLT3, CEBPA, MLL, and NRAS genes in leukemia cells with the clinical outcome in 872 adults younger than 60 years of age with cytogenetically normal AML. Patients...
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Source: Cancer Weekly (2008-06-03)
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