World Journal of Gastroenterology
A potential route for human tumor gene therapy
Published in Cancer Weekly, June 3rd, 2008
The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value. Inhibition of the upregulation of NHE-1 gene expression in human gastric carcinoma cells can induce intracellular acidification, resulting in apoptosis of tumor cells, which is helpful for the treatment of tumors.
This study, performed by a team led by Professor Hai-Feng Liu, is described in a research article to be published on April 14, 2008 in the World Journal of Gastroenterology.
Previous studies have proven that the...
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Source: Cancer Weekly (2008-06-03)
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