Cancer Weekly
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Adenoma
Reports from University of Birmingham advance knowledge in adenoma
June 3rd, 2008
According to recent research from Birmingham, the United Kingdom, "In most colorectal tumours, APC mutation stabilises beta-catenin and mimics elements of Wnt growth factor signalling, but the high frequency of epigenetic loss of Wnt antagonists indicates an additional role for ligand-mediated Wnt signalling. Here, we have investigated the expression of key components of beta-catenin-independent Wnt response pathways to determine whether their profiles change during the transition from normal mucosa to colorectal adenomas." "Transcription of the Wnt/planar cell polarity pathway determinant NKD1 (naked cuticle homologue 1) was induced in adenomas by a median 135-fold and...
Source: Cancer Weekly (2008-06-03)
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