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Cancer Weekly

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Adrenocortical Cancer



Data on adrenocortical cancer published by researchers at University of California



June 3rd, 2008

According to a study from the United States, " The most common genetic change observed in adrenocortical carcinoma is loss of heterozygozity on chromosome 11q13. As genes on this chromosome may be important in the pathogenesis of adrenocortical carcinoma, we compared their expression profile between benign and malignant adrenocortical tissue."

" We used the Affymetrix GeneChip (U133 plus 2.0) array in 54 adrenocortical tumors (11 carcinoma and 43 benign). Differential gene expression was defined as a twofold higher or lower gene expression level (p < 0.05). Differentially expressed genes on microarray analysis were validated by real-time quantitative...


Source: Cancer Weekly (2008-06-03)

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