Cancer Weekly
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Angiogenesis
Studies from E.J. Jacobs and colleagues yield new information about angiogenesis
June 3rd, 2008
"Angiogenesis is required for development and progression of prostate cancer. Potentially functional single nucleotide polymorphisms (SNP) in genes important in prostate angiogenesis (VEGF, HIF1A, and NOS3) have previously been associated with risk or severity of prostate cancer," scientists in the United States report. "Prostate cancer cases (n = 1,425) and controls (n = 1,453) were selected from the Cancer Prevention Study 11 Nutrition Cohort. We examined associations between 58 SNPs in nine angiogenesis-related candidate genes (EGF, LTA, HIF1A, HIF1AN, MMP2, MMP9, NOS2A, NOS3, VEGF) and risk of overall and advanced prostate cancer. Unconditional logistic regression...
Source: Cancer Weekly (2008-06-03)
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