Cancer Weekly
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Angiogenesis
Studies in the area of angiogenesis reported from D. Sliva and co-researchers
June 3rd, 2008
According to a study from the United States, "The antitumour activity of a medicinal mushroom Phellinus linteus (PL), through the stimulation of immune system or the induction of apoptosis, has been recently described. However, the molecular mechanisms responsible for the inhibition of invasive behaviour of cancer cells remain to be addressed." "In the present study, we demonstrate that PL inhibits proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of highly invasive human breast cancer cells. The growth inhibition of MDA-MB-231 cells is mediated by the cell cycle arrest at S phase through the upregulation of p27(Kip1)...
Source: Cancer Weekly (2008-06-03)
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