Corneal Dystrophies
Reports outline corneal dystrophies study results from University of Louisville, Health Science Center
Published in Cancer Weekly, June 3rd, 2008
A report, 'Zeb1 mutant mice as a model of posterior corneal dystrophy,' is newly published data in Investigative Ophthalmology & Visual Science. "The zinc finger transcription factor Zeb1 binds to E-box-like sequences and is important for maintaining repression of epithelial specification genes in vivo. Overexpression of Zeb1 in cancer triggers epithelial-mesenchymal transition, which facilitates metastasis," scientists in the United States report.
"The mutation of ZEB1 in humans is linked to posterior polymorphous corneal dystrophy (PPCD), in which an epithelial transition of the corneal endothelium is associated with abnormal endothelial proliferation. The...
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Source: Cancer Weekly (2008-06-03)
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