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Saint John's Health Center

DNA Modification Seen in Colorectal Tumors Helps Predict Outcomes, John Wayne Cancer Institute Researchers Find

Published in Cancer Weekly, June 10th, 2008

An international study led by researchers at the John Wayne Cancer Institute at Saint John's Health Center has found that modifications to DNA found on multiple chromosomes in tumors can help to predict outcomes in patients with early-stage rectal cancer.

The study, published in the May 10, 2008, issue of the Journal of Clinical Oncology, also suggests that classification of rectal cancer based upon these genetic changes should be evaluated as means of predicting reoccurrence and perhaps re-evaluating treatment strategies.

Cancer of the rectum, which is diagnosed in more than 40,000 people each year, is characterized by the development of malignant...

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