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Cancer Gene Therapy
Report summarizes cancer gene therapy study findings from Wonkwang University, Department of Internal Medicine
June 10th, 2008
Current study results from the report, 'Suppression of Nrf2-driven heme oxygenase-1 enhances the chemosensitivity of lung cancer A549 cells toward cisplatin,' have been published. "Heme oxygenase-1 (HO-1) is highly expressed in various tumor tissues and plays an important role in tumor cell growth through anti-oxidative and anti-apoptotic effects. Herein, we demonstrate that A549 cells express high levels of HO-1, Nrf2, and NF-kappaB compared to other lung cancer cell lines, including H23, H157, and H460," scientists in Korea report. "Ectopic expression of HO-1 small interfering RNA (siRNA) increased both apoptosis and degradation of procaspase-3. Transfection studies...
Source: Cancer Weekly (2008-06-10)
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