Glioma

Research from M. Tiwari and co-researchers in the area of glioma published

Published in Cancer Weekly, June 10th, 2008

According to a study from Lucknow, India, "The question whether chemotherapy-induced autophagy is causative to the demise of the cells or a part of the survival mechanism activated during cellular distress is unclear. Others and we have previously demonstrated apoptosis-inducing capacity of N-(4-hydroxyphenyl)retinamide (4-HPR) in malignant glioma cells."

"We provide evidences of 4-HPR-induced autophagy at a lower concentration (5 mc M). Suboptimal dose of 4-HPR treatment of malignant glioma cell lines increased G(2)/M arrest, whereas cell accumulated in S phase at a higher concentration. 4-HPR-induced autophagy was associated with acidic vacuole [acidic vesicular...

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Source: Cancer Weekly (2008-06-10)

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